CRM External Seminar: Dr Prakash Ramachandran, Centre for Inflammation Research, University of Edinburgh, UK Talk title Dissecting macrophage phenotypes in liver fibrosis using single-cell and spatial omics technologies Host Steve Pollard Abstract In this talk, Prakash will discuss the role of macrophages in regulating liver fibrosis and how his group has utilised single-cell RNA-seq to study macrophage heterogeneity in human liver and identify fibrosis-associated cell states in patients with advanced fibrosis. He will cover how they are now using single-nuclear RNA-seq and spatial omics approaches (Visium, Stereo-seq and CODEX) to enable the study of macrophages during earlier-stage fibrosis in clinical samples. Bio Prakash Ramachandran is an MRC Senior Clinical Fellow at the Centre for Inflammation Research and an Honorary Consultant Hepatologist at the Royal Infirmary of Edinburgh. He undertook medical training at the University of Edinburgh, graduating in 2003. He subsequently completed a Wellcome Trust funded PhD (2008-2011), an MRC Clinician Scientist Fellowship (2016-2020), and was recently awarded an MRC Senior Clinical Fellowship (2022-2027) entitled “Therapeutic Targeting of Pathogenic Scar-associated Macrophages in the Fibrotic Niche of Chronic Liver Disease”. His group’s research is focussed on using single-cell and spatial -omics approaches to study the role of the immune system in regulating liver injury and fibrosis. Specifically, his work has defined the heterogeneity of hepatic macrophages in chronic liver disease, identifying key populations with orchestrate fibrosis and fibrosis regression. May 04 2023 12.00 - 13.00 CRM External Seminar: Dr Prakash Ramachandran, Centre for Inflammation Research, University of Edinburgh, UK Dr Prakash Ramachandran, Centre for Inflammation Research, University of Edinburgh This event is a Centre for Regenerative Medicine (CRM) external seminar which will take place in the seminar room, 1st floor, CRM. Where to find us
CRM External Seminar: Dr Prakash Ramachandran, Centre for Inflammation Research, University of Edinburgh, UK Talk title Dissecting macrophage phenotypes in liver fibrosis using single-cell and spatial omics technologies Host Steve Pollard Abstract In this talk, Prakash will discuss the role of macrophages in regulating liver fibrosis and how his group has utilised single-cell RNA-seq to study macrophage heterogeneity in human liver and identify fibrosis-associated cell states in patients with advanced fibrosis. He will cover how they are now using single-nuclear RNA-seq and spatial omics approaches (Visium, Stereo-seq and CODEX) to enable the study of macrophages during earlier-stage fibrosis in clinical samples. Bio Prakash Ramachandran is an MRC Senior Clinical Fellow at the Centre for Inflammation Research and an Honorary Consultant Hepatologist at the Royal Infirmary of Edinburgh. He undertook medical training at the University of Edinburgh, graduating in 2003. He subsequently completed a Wellcome Trust funded PhD (2008-2011), an MRC Clinician Scientist Fellowship (2016-2020), and was recently awarded an MRC Senior Clinical Fellowship (2022-2027) entitled “Therapeutic Targeting of Pathogenic Scar-associated Macrophages in the Fibrotic Niche of Chronic Liver Disease”. His group’s research is focussed on using single-cell and spatial -omics approaches to study the role of the immune system in regulating liver injury and fibrosis. Specifically, his work has defined the heterogeneity of hepatic macrophages in chronic liver disease, identifying key populations with orchestrate fibrosis and fibrosis regression. May 04 2023 12.00 - 13.00 CRM External Seminar: Dr Prakash Ramachandran, Centre for Inflammation Research, University of Edinburgh, UK Dr Prakash Ramachandran, Centre for Inflammation Research, University of Edinburgh This event is a Centre for Regenerative Medicine (CRM) external seminar which will take place in the seminar room, 1st floor, CRM. Where to find us
May 04 2023 12.00 - 13.00 CRM External Seminar: Dr Prakash Ramachandran, Centre for Inflammation Research, University of Edinburgh, UK Dr Prakash Ramachandran, Centre for Inflammation Research, University of Edinburgh
