CRM External Seminar: Dr Shane Herbert, Wellcome Trust Senior Research Fellow, University of Manchester, UK Dr Shane Herbert Wellcome Trust Senior Research Fellow, Division of Molecular and Cellular Function, Faculty of Biology Medicine and Health, University of Manchester Contact details Email: shane.herbert@manchester.ac.uk Talk title Morphogenetic cues encoded in cell shape Hosts Elaine Emmerson (CRM) and Tijana Mitic (CVS) Bio Shane Herbert is a Wellcome Trust Senior Research Fellow in the Faculty of Biology, Medicine and Health at the University of Manchester. He studied for his PhD at the University of Leeds prior to postdoctoral studies in the lab of Didier Stainier at the University of California, San Francisco. He then moved to the University of Manchester as a Wellcome Trust Career Development Fellow in 2011 to establish his group. Shane's lab is interested in how cells communicate and coordinate their behaviour to collectively generate new tissues, with a focus on blood vessel formation. To do this his lab uses a multidisciplinary approach that integrates in vivo live-imaging studies in the zebrafish model system, in vitro micropatterning approaches and computational modelling. In particular, current research interests include defining the role that cell shape dynamics play in directing core decision-making processes underpinning tissue morphogenesis. Abstract Tissue building is associated with dramatic changes in cell shape. Whilst this cell shape change clearly defines final tissue form, how it impacts the critical decision-making processes underpinning tissue formation is unclear. His work reveals that cell shape itself creates key instructive cues that direct fundamental cell fate and behaviour decisions driving tissue morphogenesis. In particular, Shane will discuss recent unpublished work defining how interphase cell shape acts to break the symmetry of cell division to trigger key asymmetric divisions coordinating tissue formation. Using in vivo live imaging of vertebrate blood vessel morphogenesis, in vitro micropatterning tools and in silico modelling, he will show the acquisition of distinct cell geometries in interphase modulate the dynamics of mitotic cell rounding in division, generating predictable asymmetries in both daughter cell size and partitioning of fate determinants. Hence, pre-mitotic cell shape acts as a conserved instructive cue that robustly defines post-mitotic daughter cell state and behaviour during tissue formation. Feb 09 2023 12.00 - 13.00 CRM External Seminar: Dr Shane Herbert, Wellcome Trust Senior Research Fellow, University of Manchester, UK Dr Shane Herbert, Wellcome Trust Senior Research Fellow, University of Manchester This event will be jointly hosted by the Centre for Regenerative Medicine (CRM) and the Centre for Cardiovascular Science (CVS). The talk will take place in the seminar room, 1st floor, CRM. Where to find us
CRM External Seminar: Dr Shane Herbert, Wellcome Trust Senior Research Fellow, University of Manchester, UK Dr Shane Herbert Wellcome Trust Senior Research Fellow, Division of Molecular and Cellular Function, Faculty of Biology Medicine and Health, University of Manchester Contact details Email: shane.herbert@manchester.ac.uk Talk title Morphogenetic cues encoded in cell shape Hosts Elaine Emmerson (CRM) and Tijana Mitic (CVS) Bio Shane Herbert is a Wellcome Trust Senior Research Fellow in the Faculty of Biology, Medicine and Health at the University of Manchester. He studied for his PhD at the University of Leeds prior to postdoctoral studies in the lab of Didier Stainier at the University of California, San Francisco. He then moved to the University of Manchester as a Wellcome Trust Career Development Fellow in 2011 to establish his group. Shane's lab is interested in how cells communicate and coordinate their behaviour to collectively generate new tissues, with a focus on blood vessel formation. To do this his lab uses a multidisciplinary approach that integrates in vivo live-imaging studies in the zebrafish model system, in vitro micropatterning approaches and computational modelling. In particular, current research interests include defining the role that cell shape dynamics play in directing core decision-making processes underpinning tissue morphogenesis. Abstract Tissue building is associated with dramatic changes in cell shape. Whilst this cell shape change clearly defines final tissue form, how it impacts the critical decision-making processes underpinning tissue formation is unclear. His work reveals that cell shape itself creates key instructive cues that direct fundamental cell fate and behaviour decisions driving tissue morphogenesis. In particular, Shane will discuss recent unpublished work defining how interphase cell shape acts to break the symmetry of cell division to trigger key asymmetric divisions coordinating tissue formation. Using in vivo live imaging of vertebrate blood vessel morphogenesis, in vitro micropatterning tools and in silico modelling, he will show the acquisition of distinct cell geometries in interphase modulate the dynamics of mitotic cell rounding in division, generating predictable asymmetries in both daughter cell size and partitioning of fate determinants. Hence, pre-mitotic cell shape acts as a conserved instructive cue that robustly defines post-mitotic daughter cell state and behaviour during tissue formation. Feb 09 2023 12.00 - 13.00 CRM External Seminar: Dr Shane Herbert, Wellcome Trust Senior Research Fellow, University of Manchester, UK Dr Shane Herbert, Wellcome Trust Senior Research Fellow, University of Manchester This event will be jointly hosted by the Centre for Regenerative Medicine (CRM) and the Centre for Cardiovascular Science (CVS). The talk will take place in the seminar room, 1st floor, CRM. Where to find us
Feb 09 2023 12.00 - 13.00 CRM External Seminar: Dr Shane Herbert, Wellcome Trust Senior Research Fellow, University of Manchester, UK Dr Shane Herbert, Wellcome Trust Senior Research Fellow, University of Manchester
