CRM External Seminar: Ewa Paluch, Department of Physiology, Development and Neuroscience, University of Cambridge, UK Talk title Cross-talk between cell mechanics, cell shape and cell fate Host Katrin Ottersbach Abstract A precise control of cell morphology is key for cell physiology, and cell shape deregulation is at the heart of many pathological disorders. Furthermore, transitions in cellular fate and state are associated with changes in cell shape, and strong evidence points to the existence of feedbacks between mechanics, morphology and fate decisions. Cell morphology is intrinsically controlled by mechanical forces acting on the cell surface, to understand shape it is thus essential to investigate the regulation of cellular mechanics. We investigate how cellular mechanical properties are regulated, how they drive cellular shape changes, and the cross-talk between mechanics and state in cellular transitions in development and in stem cells. I will present a project on mechanosensing during early differentiation in embryonic stem cells, and a general framework we have developed to investigate the coupling between fate and shape during cellular transitions. Bio Ewa Paluch graduated in Physics from the Ecole Normale Supérieure in Lyon in 2001, and did a PhD in Biophysics at the Curie Institute in Paris between 2001 to 2005. She started her research group in 2006 at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden (joint appointment with the IIMCB, Warsaw). In 2013, she was appointed Professor of Cell Biophysics at the MRC LMCB, University College London. From 2014 to 2018, she also headed the new UCL Institute for the Physics of Living Systems, which promotes collaborations between physicists and biologists at UCL. In 2018 she was elected Chair of Anatomy at the University of Cambridge. Ewa is the 19th Professor of Anatomy at Cambridge, and the first woman to hold this Chair in its 300-year history. She has received a number of awards, including the Hooke Medal from the British Society for Cell Biology in 2017 and the Blavatnik Award for Young Scientists in the UK in 2019. She became Fellow of Trinity College Cambridge, and was elected EMBO member in 2018. Ewa's lab combines molecular and cell biology, biophysics, quantitative imaging and modelling to investigate the principles underlying cellular morphogenesis. The lab’s research directions span cell surface mechanics regulation, the control of cell shape during cell division and migration, and the cross-talk between cell mechanics, cell shape and cell fate. Lab website: https://paluchlab.uk Feb 01 2024 12.00 - 13.00 CRM External Seminar: Ewa Paluch, Department of Physiology, Development and Neuroscience, University of Cambridge, UK Ewa Paluch, Department of Physiology, Development and Neuroscience, University of Cambridge, UK This event is a Centre for Regenerative Medicine (CRM) external seminar which will take place in the seminar room, 1st floor, IRR North. Where to find us
CRM External Seminar: Ewa Paluch, Department of Physiology, Development and Neuroscience, University of Cambridge, UK Talk title Cross-talk between cell mechanics, cell shape and cell fate Host Katrin Ottersbach Abstract A precise control of cell morphology is key for cell physiology, and cell shape deregulation is at the heart of many pathological disorders. Furthermore, transitions in cellular fate and state are associated with changes in cell shape, and strong evidence points to the existence of feedbacks between mechanics, morphology and fate decisions. Cell morphology is intrinsically controlled by mechanical forces acting on the cell surface, to understand shape it is thus essential to investigate the regulation of cellular mechanics. We investigate how cellular mechanical properties are regulated, how they drive cellular shape changes, and the cross-talk between mechanics and state in cellular transitions in development and in stem cells. I will present a project on mechanosensing during early differentiation in embryonic stem cells, and a general framework we have developed to investigate the coupling between fate and shape during cellular transitions. Bio Ewa Paluch graduated in Physics from the Ecole Normale Supérieure in Lyon in 2001, and did a PhD in Biophysics at the Curie Institute in Paris between 2001 to 2005. She started her research group in 2006 at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden (joint appointment with the IIMCB, Warsaw). In 2013, she was appointed Professor of Cell Biophysics at the MRC LMCB, University College London. From 2014 to 2018, she also headed the new UCL Institute for the Physics of Living Systems, which promotes collaborations between physicists and biologists at UCL. In 2018 she was elected Chair of Anatomy at the University of Cambridge. Ewa is the 19th Professor of Anatomy at Cambridge, and the first woman to hold this Chair in its 300-year history. She has received a number of awards, including the Hooke Medal from the British Society for Cell Biology in 2017 and the Blavatnik Award for Young Scientists in the UK in 2019. She became Fellow of Trinity College Cambridge, and was elected EMBO member in 2018. Ewa's lab combines molecular and cell biology, biophysics, quantitative imaging and modelling to investigate the principles underlying cellular morphogenesis. The lab’s research directions span cell surface mechanics regulation, the control of cell shape during cell division and migration, and the cross-talk between cell mechanics, cell shape and cell fate. Lab website: https://paluchlab.uk Feb 01 2024 12.00 - 13.00 CRM External Seminar: Ewa Paluch, Department of Physiology, Development and Neuroscience, University of Cambridge, UK Ewa Paluch, Department of Physiology, Development and Neuroscience, University of Cambridge, UK This event is a Centre for Regenerative Medicine (CRM) external seminar which will take place in the seminar room, 1st floor, IRR North. Where to find us
Feb 01 2024 12.00 - 13.00 CRM External Seminar: Ewa Paluch, Department of Physiology, Development and Neuroscience, University of Cambridge, UK Ewa Paluch, Department of Physiology, Development and Neuroscience, University of Cambridge, UK
