CRM External Seminar: Prof Dr Timm Schroeder, ETH Zürich, D-BSSE, Department of Biosystems Science and Engineering, Switzerland Talk title Long-term single-cell quantification: New tools for old questions Host Katrin Ottersbach Abstract Surprisingly many long-standing questions in stem cell research remain disputed. One major reason is the fact that we usually analyze only populations of cells - rather than individual cells – and at very few time points of an experiment – rather than continuously. We therefore develop imaging approaches and software to image, segment, and track cells long-term, and to quantify e.g. divisional history, position, interaction, and protein expression or activity of all individual cells over many days and generations. Live-cell imaging is complemented by novel large-volume multi-color 3D imaging with up to single-molecule sensitivity. Dedicated software, machine learning and computational modeling enable data acquisition, curation, and analysis. Custom-made microfluidics and other hardware devices improve single-cell observation, dynamic manipulation, molecular analysis, and the high-dimensional snapshot ‘omics’ quantification of individual cells with known history, kinship and dynamics. The resulting continuous single-cell data is used for analyzing the dynamics, interplay, and functions of signaling pathway and transcription factor networks in controlling the fate decisions of hematopoietic, pluripotent, and neural stem cells. Bio Timm Schroeder investigates the molecular control of mammalian stem and progenitor cell fates at the interface of biology, medicine, informatics, and engineering. He pioneered bio-imaging approaches for live long-term single cell quantification, and combines molecular cell biology, imaging, software development and hardware engineering. Timm studied Biology, PhD work in Munich/Germany and Kyoto/Japan, postdoc in Munich and Kobe/Japan. Principal Investigator at Helmholtz Center Munich late 2004, tenured 2008, director research unit Stem Cell Dynamics 2011. Since 2013 full professor at ETH Zurich, Department of Biosystems Science and Engineering (deputy/department head 2015-19) in Basel/Switzerland. Nov 16 2023 12.00 - 13.00 CRM External Seminar: Prof Dr Timm Schroeder, ETH Zürich, D-BSSE, Department of Biosystems Science and Engineering, Switzerland Prof Dr Timm Schroeder, ETH Zürich, D-BSSE, Department of Biosystems Science and Engineering, Switzerland This event is a Centre for Regenerative Medicine (CRM) external seminar which will take place in the seminar room, 1st floor, IRR North. Where to find us
CRM External Seminar: Prof Dr Timm Schroeder, ETH Zürich, D-BSSE, Department of Biosystems Science and Engineering, Switzerland Talk title Long-term single-cell quantification: New tools for old questions Host Katrin Ottersbach Abstract Surprisingly many long-standing questions in stem cell research remain disputed. One major reason is the fact that we usually analyze only populations of cells - rather than individual cells – and at very few time points of an experiment – rather than continuously. We therefore develop imaging approaches and software to image, segment, and track cells long-term, and to quantify e.g. divisional history, position, interaction, and protein expression or activity of all individual cells over many days and generations. Live-cell imaging is complemented by novel large-volume multi-color 3D imaging with up to single-molecule sensitivity. Dedicated software, machine learning and computational modeling enable data acquisition, curation, and analysis. Custom-made microfluidics and other hardware devices improve single-cell observation, dynamic manipulation, molecular analysis, and the high-dimensional snapshot ‘omics’ quantification of individual cells with known history, kinship and dynamics. The resulting continuous single-cell data is used for analyzing the dynamics, interplay, and functions of signaling pathway and transcription factor networks in controlling the fate decisions of hematopoietic, pluripotent, and neural stem cells. Bio Timm Schroeder investigates the molecular control of mammalian stem and progenitor cell fates at the interface of biology, medicine, informatics, and engineering. He pioneered bio-imaging approaches for live long-term single cell quantification, and combines molecular cell biology, imaging, software development and hardware engineering. Timm studied Biology, PhD work in Munich/Germany and Kyoto/Japan, postdoc in Munich and Kobe/Japan. Principal Investigator at Helmholtz Center Munich late 2004, tenured 2008, director research unit Stem Cell Dynamics 2011. Since 2013 full professor at ETH Zurich, Department of Biosystems Science and Engineering (deputy/department head 2015-19) in Basel/Switzerland. Nov 16 2023 12.00 - 13.00 CRM External Seminar: Prof Dr Timm Schroeder, ETH Zürich, D-BSSE, Department of Biosystems Science and Engineering, Switzerland Prof Dr Timm Schroeder, ETH Zürich, D-BSSE, Department of Biosystems Science and Engineering, Switzerland This event is a Centre for Regenerative Medicine (CRM) external seminar which will take place in the seminar room, 1st floor, IRR North. Where to find us
Nov 16 2023 12.00 - 13.00 CRM External Seminar: Prof Dr Timm Schroeder, ETH Zürich, D-BSSE, Department of Biosystems Science and Engineering, Switzerland Prof Dr Timm Schroeder, ETH Zürich, D-BSSE, Department of Biosystems Science and Engineering, Switzerland
