CRM External Seminar: Professor Ian Adams, Group leader, MRC Human Genetics Unit, Institute of Genetics and Cancer, UoE Professor Ian Adams MRC Human Genetics Unit, Institute of Genetics and Cancer, UoE Contact details Email: Ian.Adams@ed.ac.uk Talk title Preventing Aneuploidy in the Mammalian Germline Host Rob Illingworth Abstract Our genetic information is transmitted from generation to generation by germ cells. These cells are responsible for shuffling the genetic information that we inherit from our parents to generate to combinations of genetic alleles, and for ensuring that the correct number of chromosomes are transmitted to our offspring. However, defects in these processes are relatively common in humans, with age-dependent chromosome segregation errors in meiosis in the female germline being a major cause of infertility, miscarriage and inherited genetic disorders such as Down syndrome. Understanding the mechanisms involved in these processes has the potential to impact on reproductive technologies and the incidence of one of the most common types of inherited human genetic disease. Many genes involved in pairing and segregating meiotic chromosomes have been identified in model organisms, but significant gaps remain in understanding these processes in mammals. We have used mouse genetic models to trap intermediates in meiotic chromosome pairing and identify molecules linking homologous chromosomes at recombination sites, and to identify pathways that help maintain the physical links between homologous chromosomes and prevent chromosome segregation errors in the female germline. Our findings suggest that mammals have evolved specific mechanisms that modulate ubiquitin-dependent turnover of chromosome-associated proteins in meiotic oocytes, and that targeting these pathways provides a potential route to reduce the high rates of meiotic chromosome segregation errors in older eggs. Bio Ian Adams studied molecular biology as an undergraduate at the University of Edinburgh before carrying out his PhD research on chromosome segregation in yeast at the MRC Laboratory of Molecular Biology in Cambridge. He then undertook post-doctoral research on mouse germ cell development in at the Gurdon Institute in Cambridge, before returning to Edinburgh supported by a fellowship from the Lister Institute of Preventive Medicine. Ian Adams' research at the MRC Human Genetics Unit in the Institute of Genetics and Cancer is aimed at understanding how genetic and chromosomal stability is maintained in mammalian germ cells. Nov 30 2023 12.00 - 13.00 CRM External Seminar: Professor Ian Adams, Group leader, MRC Human Genetics Unit, Institute of Genetics and Cancer, UoE Professor Ian Adams, Group leader, MRC Human Genetics Unit, Institute of Genetics and Cancer, UoE This event is a Centre for Regenerative Medicine (CRM) external seminar which will take place in the seminar room, 1st floor, IRR North. Where to find us
CRM External Seminar: Professor Ian Adams, Group leader, MRC Human Genetics Unit, Institute of Genetics and Cancer, UoE Professor Ian Adams MRC Human Genetics Unit, Institute of Genetics and Cancer, UoE Contact details Email: Ian.Adams@ed.ac.uk Talk title Preventing Aneuploidy in the Mammalian Germline Host Rob Illingworth Abstract Our genetic information is transmitted from generation to generation by germ cells. These cells are responsible for shuffling the genetic information that we inherit from our parents to generate to combinations of genetic alleles, and for ensuring that the correct number of chromosomes are transmitted to our offspring. However, defects in these processes are relatively common in humans, with age-dependent chromosome segregation errors in meiosis in the female germline being a major cause of infertility, miscarriage and inherited genetic disorders such as Down syndrome. Understanding the mechanisms involved in these processes has the potential to impact on reproductive technologies and the incidence of one of the most common types of inherited human genetic disease. Many genes involved in pairing and segregating meiotic chromosomes have been identified in model organisms, but significant gaps remain in understanding these processes in mammals. We have used mouse genetic models to trap intermediates in meiotic chromosome pairing and identify molecules linking homologous chromosomes at recombination sites, and to identify pathways that help maintain the physical links between homologous chromosomes and prevent chromosome segregation errors in the female germline. Our findings suggest that mammals have evolved specific mechanisms that modulate ubiquitin-dependent turnover of chromosome-associated proteins in meiotic oocytes, and that targeting these pathways provides a potential route to reduce the high rates of meiotic chromosome segregation errors in older eggs. Bio Ian Adams studied molecular biology as an undergraduate at the University of Edinburgh before carrying out his PhD research on chromosome segregation in yeast at the MRC Laboratory of Molecular Biology in Cambridge. He then undertook post-doctoral research on mouse germ cell development in at the Gurdon Institute in Cambridge, before returning to Edinburgh supported by a fellowship from the Lister Institute of Preventive Medicine. Ian Adams' research at the MRC Human Genetics Unit in the Institute of Genetics and Cancer is aimed at understanding how genetic and chromosomal stability is maintained in mammalian germ cells. Nov 30 2023 12.00 - 13.00 CRM External Seminar: Professor Ian Adams, Group leader, MRC Human Genetics Unit, Institute of Genetics and Cancer, UoE Professor Ian Adams, Group leader, MRC Human Genetics Unit, Institute of Genetics and Cancer, UoE This event is a Centre for Regenerative Medicine (CRM) external seminar which will take place in the seminar room, 1st floor, IRR North. Where to find us
Nov 30 2023 12.00 - 13.00 CRM External Seminar: Professor Ian Adams, Group leader, MRC Human Genetics Unit, Institute of Genetics and Cancer, UoE Professor Ian Adams, Group leader, MRC Human Genetics Unit, Institute of Genetics and Cancer, UoE
