CRM External Seminar: Professor Neil Henderson, Centre for Inflammation Research, University of Edinburgh, UK

Professor Neil Henderson

Chair of Tissue Repair and Regeneration; Wellcome Trust Senior Research Fellow in Clinical Science; Honorary Consultant Hepatologist – Royal Infirmary Edinburgh

Contact details

Talk title

Multimodal decoding of human liver regeneration

Host

Elaine Emmerson

Bio

Neil Henderson undertook medical training in Edinburgh and London before completing a Wellcome Trust-funded PhD at the MRC Centre for Inflammation Research, Edinburgh. He then trained in hepatology and was awarded a Wellcome Trust Intermediate Fellowship, during which time he spent a 3-year post-doctoral period based in Dean Sheppard's lab at the University of California, San Francisco, USA. Neil was then awarded a Wellcome Trust Senior Research Fellowship in Clinical Science to investigate novel mechanisms of organ fibrosis and regeneration, using cutting-edge approaches including the rapidly evolving field of single cell genomics.    

Abstract

To advance our understanding of human liver regeneration and to inform design of pro-regenerative therapies, we have used multimodal single cell genomics approaches (including paired single-nuclei RNAseq combined with spatial profiling of healthy and acute liver failure explant human liver samples) to generate a single-cell, pan-lineage atlas of human liver regeneration.

In this seminar, Neil will discuss how these approaches, in conjunction with functional interrogation of corollary cellular subpopulations in mouse models of liver regeneration, have allowed us to uncover novel cell states and unanticipated aspects of liver regeneration.